A mouse model harboring this mutation recapitulates the immunohistochemical ... and dots indicate heterozygous carriers. Panel C shows a schematic representation of a dystroglycan mutant protein ...

In humans, the mutation effectively breaks one copy of the gene (a mechanism they recently confirmed), so the team generated a so-called "heterozygous" mouse model in which one copy of the Grin2a ...

The F1 heterozygous offspring are analyzed using next-generation sequencing of amplicons to ensure that the delivered mice share the ... if any have inherited a mutation at a potential predicted ...

The researchers found that heterozygous mice (those with a moderate number of mutated mitochondria) seemed to amplify leukemia growth. Homozygous mice with a high number of mutations had the ...

Instead, the researchers used a leukemia mouse model with a defective genetic proofreading system called Polg, which gradually accrues mtDNA mutations. By disrupting Polg’s proofreading function in ...

That may be because most mouse models of Alzheimer's disease harbor the Swedish mutation. This has so far hindered efforts to study the beneficial effects of the Icelandic mutation. Now ...

On the other hand, if you’re heterozygous for a recessive mutation, you won’t get it. The normal allele takes over and you’re simply a carrier. This means your children may get it.

However, a team from the University of Tsukuba have now generated the first mouse model carrying a disease-associated mitochondrial mutation and have shown that the resulting disease is caused by ...