Figure 2: Steps in positional cloning of a recessive phenotype. F 1 hybrid mice (heterozygous for the mutation and for all of the markers) are backcrossed to the mutant stock, or hybrids are ...

RIKEN researchers have demonstrated the protective effects of a specific genetic mutation against Alzheimer's disease in ...

The mice with mutations analogous to those in the human patients also showed schizophrenia-associated behaviors. To further ...