First-in-class approach enables the generation of transgene-free hematopoietic stem cells through mechanosensitive PIEZO1 ...

Researchers use generative AI to design synthetic enhancers that can effectively control gene expression in healthy mammalian cells.

Expression of the clusterin gene in hematopoietic stem cells marks an age-related shift toward myeloid/platelet over lymphoid cell production In recent years, there has been a growing trend of an ...

Researchers identified 55 distinct hematopoietic cell states across the dataset ... These patterns reflected both early developmental blocks and lineage-biased differentiation toward myeloid ...

CARLSBAD, Calif.--(BUSINESS WIRE)--$LCTX #LineageCellTherapeutics--Lineage Cell Therapeutics, Inc. (NYSE American and TASE: LCTX), a clinical-stage biotechnology ...

Buildup of lipid peroxides can affect critical cells called hematopoietic stem cells (HSCs ... impacted HSCs and immune cells with B cell lineage (types of white blood cells) but had few effects ...

Each setting is associated with its own risks and benefits. Hematopoietic cell transplant (HCT) is a potentially curative treatment for hematologic malignancies, autoimmune disorders, and blood ...

The immune system consists of a large repertoire of cellular components that are sustained by the concerted action of hematopoietic stem and progenitor cells throughout development and the lifetime of ...

The research group aims to understand how normal blood cell formation from stem cells in the bone ... mice the impact of recurrent genetic lesions at distinct stages of hematopoietic lineage ...

The contribution of hematopoietic stem cells (HSCs) to this process was reported ... We identify CD201 as a cell surface marker that allows the separation of HSCs to distinct lineage bias, and report ...

Hematopoietic stem cells reside in spatially organized microenvironments within the bone marrow that support their quiescence and upon activation, differentiation to lineage committed progenitors and ...