In a major overhaul, the U.S. Department of Health and Human Services will lay off 10,000 workers and shut down entire agencies, including ones that oversee billions of dollars in funds for addiction services and community health centers across the country.

The Department of Health and Human Services on Thursday announced plans to cut 10,000 employees amid an executive order from President Donald Trump to downsize federal agencies.

The Food and Drug Administration, responsible for setting standards for Americans’ foods and medications, will shed 3,500 workers, while the Centers