A vaccine's ability to generate long-lasting, high-affinity antibodies hinges on a delicate balance. Upon exposure to a ...

An effective HIV-1 vaccine must therefore elicit antibodies that can neutralize many variants of the virus. While broadly neutralizing antibodies (bnAbs) have been isolated from HIV-1 infected ...

Dolutegravir plus lamivudine shows comparable efficacy and safety with standard-of-care three-drug regimen in patients with HIV without preliminary drug resistance testing in a phase 4 trial.

Two more people have potentially been cured of HIV after undergoing stem cell transplants. Like others, the patients received stem cells from donors with a mutation that makes them resistant to HIV.

Germinal centers rapidly introduce mutations into an otherwise average ... highly evolved antibodies for difficult targets, such as HIV—or accelerate to the "banking" phase to preserve effective ...

A Norwegian man has been free of the virus for nearly two and a half years following treatment and is likely cured of HIV.

NNRTIs bind to a hydrophobic pocket near the catalytic site of HIV-1 RT and inactivate enzymatic activity. NNRTI-resistance mutations & their mechanism of drug resistance The most prevalent NNRTI ...

Successful high-affinity B cells can proliferate under special conditions that reduce the risk of mutation. Capturing this ...

A single shot of a new formulation of the antiretroviral drug lenacapavir could potentially provide protection against HIV ...

Emory University's pioneering work with a class of small molecules known as JAK (janus kinase) inhibitors continues to show how HIV might be cured ...

A vaccine's ability to generate long-lasting, high-affinity antibodies hinges on a delicate balance. Upon exposure to a vaccine or pathogen, B cells scramble to refine their defenses, rapidly mutating ...