“Our data found a new function of this complex,” Krainc told Alzforum ... In COMMD3 knockouts, these proteins were captured by post-Golgi vesicles, some of which appeared to be early endosomes (image ...

histolytica serine proteinase; EhSTIRP = Serine threonine isoleucine-rich protein; KERP1 = Lysine and glutamic acid-rich protein-1; MUC2 = Secretory mucin; LPPG = Lipophosphopeptidoglycan ...

The next question was how to repair the damaged Golgi in ageing cells. The answer came from an unexpected source: extracellular vesicles (EVs) released by stem cell aggregates (Figure 1). Stem cell ...

Using different cell line models each with their own standard culture conditions further challenged the complex metabolomics data analysis. A further constraint of our study was the necessity to limit ...

Figure 2. Schematic diagram of the cGAS-STING pathway activation and downstream signaling. (COP, coat protein; ERGIC, endoplasmic reticulum-Golgi intermediate compartment; ISGs, interferon-stimulated ...

We provide evidence that Upd2 transport requires Rab5- and Rab7-mediated endocytic sorting and Lbm-dependent vesicle trafficking. Our study thus uncovers an inter-organ communication in the control of ...

Keratoconus is a bilateral and asymmetric degenerative eye disease that causes corneal thinning and bowing, leading to irregular astigmatism and vision loss. Although environmental and genetic factors ...

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China University of Chinese Academy of Sciences, Beijing 100049, China Shanghai Institute of Materia Medica, ...