Complex traits are influenced by genes and the environment, but especially the latter is difficult to pin down. This important study uses C. elegans to demonstrate that non-genetic differences in gene ...

This study presents a valuable advance for the analysis of gene expression variation at the level of individual cells by introducing a novel reference-free framework that can detect splicing, fusion, ...

Transcription of DNA into mRNA and translation of mRNA into proteins are two major processes underlying gene expression ... the molecular mechanisms that impact both processes in eukaryotic cells of ...

A eukaryote is any cell ... eukaryotic cells emerged. Additionally, genomic analyses of modern eukaryotes indicate that their ancestors likely acquired genes from multiple sources, not just from the ...

The TRAC gene is a gene and a protein that's necessary for the expression of the T-cell receptor. Each T cell recognizes a different target, and those T-cell receptors—if we get T cells infused ...

Previous research has found differences in gene expression between humans and chimpanzees, and that human cells tend to have higher gene expression, but the picture was blurry. The brain is made ...

Data on gene therapy with hematopoietic stem-cell (HSC)–based expression of factor VIII for the treatment of severe hemophilia A are lacking. We conducted a single-center study involving five ...

This year’s Nobel Prize in Physiology, or Medicine, awarded to Victor Ambros and Gary Ruvkun, is for their discovery of microRNA, small RNA regulators of gene expression in eukaryotes ...

A research team has now discovered an important function of antisense RNA (asRNA): the researchers found that asRNA acts as a 'superhighway' in cell transport and thus accelerates gene expression.

From gene-corrected cell therapies to a new CAR-T, the cell and gene therapy space looks to expand its reach into the market. In 2023, cell and gene therapy saw an unprecedented surge with seven FDA ...

However, the sequencing process destroys the cell, making it difficult to study ongoing changes in gene expression. An alternative approach developed at MIT could enable researchers to track such ...