Cell membrane proteins hide secret gateways that ... cellular activity," explains Dr. Jana Selent, coordinator of the GPCR Drug Discovery Research Group within the Biomedical Informatics Research ...

Anchored to the cell membrane, it interacts with specific lipids to regulate cell growth and division. GPCRs are integral membrane proteins that span the entire lipid bilayer and are involved in ...

Previously unknown access points in cell membrane proteins have been discovered, enabling laboratory-developed drugs to modify cell function. The discovery was made possible through computer ...

G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand – which can range from small molecules like cyclic AMP to ...

Researchers were able to observe, at atomic scale and in real time, how membrane lipids interact with G protein-coupled receptors (GPCRs) in their natural environment. These interactions reveal ...

This study employed high-throughput screening and animal models to identify FPR2, a G protein-coupled receptor (GPCR) expressed at the adipocyte plasma membrane, as a critical ceramide receptor. This ...

Researchers were able to observe, at an atomic scale and in real time, how membrane lipids interact with G protein-coupled receptors (GPCRs) in their natural environment. These interactions reveal ...

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Isolating GPCRs for structural characterisation is challenging as they are membrane bound, often losing their natural structure and function when isolated. Isolating GPCRs for structural ...

Chemistry is a branch of science that involves the study of the composition, structure and properties of matter. Often known as the central science, it is a creative discipline chiefly concerned ...