AKT, protein kinase B; CDK, cyclin dependent kinase; FoxO1, forkhead box O1; GPCR, G-protein coupled receptor; GSK3β, glycogen synthase kinase 3β; mTORC1/2, mammalian target of rapamycin complex ...

The r.m.s. deviation for the kinase domains of two very closely related ... of conservation in the three-dimensional architecture of GPCRs. This common architecture hints that GPCRs may signal ...

The SoftFocus and FieldFocus range of libraries include drug-like molecules targeted towards GPCR, ion channel, kinase and protease targets. For more information on these libraries, click here. The ...

potentially revolutionizing chronic pain treatment and GPCR drug design. Previously, authors have identified GW461484A (GW) as an inhibitor of the kinase Yck2 in the fungal pathogen Candida albicans.

Additionally, G-protein-coupled receptor (GPCR) agonists and adenosine monophosphate-activated protein kinase (AMPK) activators are emerging as potential medicines to improve insulin sensitivity ...