For both GPCR- and non-GPCR-targeted drugs, CRISPR has been applied across the drug development pipeline from early target identification and candidate screening through lead optimization and pre ...

April 15, 2007 (Vol. 27, No. 8) New Technologies and Approaches Facilitate the Discovery of Ligands G protein-coupled receptors (GPCRs) are transmembrane proteins that transduce an extracellular ...

This important study fills an gap in our knowledge of the evolution of GPCRs in holozoans, as well as the phylogeny of associated signaling pathway components such as G proteins, GRKs, and RIC8 ...

G-protein-coupled receptors (GPCRs) play a pivotal role in cellular signaling and have long been a major focus in drug discovery. These receptors regulate a vast array of physiological processes ...

AbbVie and Sosei Heptares will initially focus on developing up to three GPCR-modulating small-molecule drugs to the point at which they are ready to start clinical trials in humans, whereupon ...

Although G protein-coupled receptors (GPCRs) are crucial to the regulation of most functions in the human body, very little is known about how they work. In a new study, researchers at the Biozentrum ...

The signals of cells and their environments often involve molecules or ligands that bind to a receptor, which can trigger a biochemical process in a cell. G protein-coupled receptors (GPCRs) sit in ...

DiscoveRx® acquired the KINOMEscan kinase screening services division from San Diego-based Ambit Biosciences. With this deal DiscoveRx says that it now offers over 400 functional cell-based GPCR ...