potentially revolutionizing chronic pain treatment and GPCR drug design. Previously, authors have identified GW461484A (GW) as an inhibitor of the kinase Yck2 in the fungal pathogen Candida albicans.

Herpesvirus infection may contribute to Alzheimer’s disease through transposable element activation and neuroinflammation.

AKT, protein kinase B; CDK, cyclin dependent kinase; FoxO1, forkhead box O1; GPCR, G-protein coupled receptor; GSK3β, glycogen synthase kinase 3β; mTORC1/2, mammalian target of rapamycin complex ...

CUO-Recherche, Centre de recherche du CHU de Québec and Département d’ophtalmologie, Faculté de médecine, and Regroupement stratégique PROTEO, Université Laval, Québec, Québec G1V 0A6, Canada Centro ...

Your body produces the enzyme creatine kinase (CK) or creatine phosphokinase to keep your muscles functioning properly. Healthcare providers use the CK test to check levels of this protein in your ...

Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to ...

Stocks: Real-time U.S. stock quotes reflect trades reported through Nasdaq only; comprehensive quotes and volume reflect trading in all markets and are delayed at least 15 minutes. International ...

The Price to Earnings (P/E) ratio, a key valuation measure, is calculated by dividing the stock's most recent closing price by the sum of the diluted earnings per share from continuing operations ...

Here, we show that the MEN activating signal at SPBs is relayed to Cdc14 in the nucleolus through the dynamic localization of its terminal kinase complex Dbf2-Mob1. Cdc15, the protein kinase that ...

Proliferative signaling involves growth factors [i.e., epidermal growth factor (EGF), platelet-derived growth factor (PDGF)], their cognate receptors, often displaying tyrosine kinase activity [i.e., ...