G-protein activation and inactivation has a basic cycle, which involves agonist binding. This is in addition to receptor activation. In turn, this induces a conformational change in such a way ...

Recent breakthroughs in understanding the prostaglandin D2 (PGD2) receptor 1 (DP1) are paving the way for innovative ...

Evotec's insights into GPCRs and waveRAPID technology reveal new opportunities in drug discovery, focusing on orphan ...

One such receptor involved in relaying molecular signals is a G protein-coupled receptor (GPCR). About one-third of existing drugs work by controlling the activation of this protein. Japanese ...

A research team led by Prof. Li Yunhai from the Institute of Genetics and Developmental Biology (IGDB) of the Chinese Academy ...

In this study, JNK activity was found to regulate the function of one of the major drivers of the cell cycle, a protein complex known as the APC/C. According to this, and related research recently ...