News

Researchers reveal structural basis of prostaglandin D2 receptor DP1 activation and its implications for drug design
Recent breakthroughs in understanding the prostaglandin D2 (PGD2) receptor 1 (DP1) are paving the way for innovative ...
BioTechniques1d
Protein interaction underlying healthy brain development revealed
Researchers have captured a time-resolved video of a protein interaction essential to healthy brain development.
Mirage News1d
Scientists Unveil Structure of Prostaglandin Receptor DP1
Recent breakthroughs in understanding the prostaglandin D2 (PGD2) receptor 1 (DP1) are paving the way for innovative anti-inflammatory and ...
eLife1d
Deep Learning Reveals Endogenous Sterols as Allosteric Modulators of the GPCR-Gα Interface
Endogenous intracellular allosteric modulators of GPCRs remain largely unexplored, with limited binding and phenotype data available. This gap arises from the lack of robust computational methods for ...
'Master control switch' protein that heightens neurodegenerative disease offers new treatment target
UT Southwestern Medical Center scientists have identified a protein that appears to act as a master control switch for ...
Findings uncover new mechanism linking cohesin complex to gene regulation
Cohesin is a protein that forms a ring-shaped complex which wraps and alters the DNA molecule shape. It moves through the DNA ...
C&EN6d
Optimization of a Series of Mu Opioid Receptor (MOR) Agonists with High G Protein Signaling Bias
While mu opioid receptor (MOR) agonists are especially effective as broad ... Substantial data now exists to support the premise that G protein signaling biased MOR agonists can be effective analgesic ...
C&EN6d
Conditional and Reversible Activation of Class A and B G Protein-Coupled Receptors Using Tethered Pharmacology
Find more information on the Altmetric Attention Score and how the score is calculated. G protein-coupled receptors (GPCRs) transduce information encoded by external stimuli into an appropriate cell ...