Researchers used GPS-like tracking to observe how a key G protein-coupled receptor (GPCR) moves, revealing the core mechanism ...

G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand – which can range from small molecules like cyclic AMP to ...

Institut des Biomolécules Max Mousseron (IBMM), UMR5247, CNRS, Université de Montpellier, ENSCM, Pôle chimie Balard, 1919 route de Mende, Montpellier 34095, France ...

Center of Clinical Laboratory, Zhongshan Hospital Xiamen University, School of Medicine, Xiamen University, Xiamen 361004, China Institute of Infectious Disease, School of Medicine, Xiamen University, ...

Seeking students to join a new and growing lab that seeks to understand the molecular causes of cancer in order to develop better therapies and improve patient outcomes. Our lab seeks to understand ...

G protein-coupled receptors (GPCRs) are involved in many diseases, yet raising therapeutic antibodies against them is notoriously difficult because the transmembrane receptors contain only short ...

This study investigated the production of functional autoantibodies (fAABs) against the second loop of the G-protein-coupled receptor (GPCR) in the presence of hepatic and PAH forms of human SM.

The proteins most widely targeted by existing therapeutic agents belong to a large family of cell surface receptors named G-protein-coupled receptors (GPCRs), which relay external cues by activating G ...

angiotensin receptor type 1; Cav1, caveolin 1; ERK, extracellular signal–regulated kinase; HB-EGF, heparin-binding EGF-like growth factor; PI3K, phosphoinositide 3-kinase; p70S6K, p70 S6 kinase; PTK, ...