This important study presents a compelling theoretical framework for understanding phase separation of membrane-bound proteins, with a focus on the organization of tight junction components. By ...

Recent breakthroughs in understanding the prostaglandin D2 (PGD2) receptor 1 (DP1) are paving the way for innovative ...

Leitner studies how energy flows through molecules, especially in biological systems like protein complexes. Being named Foundation Professor includes a reward of $7,500 per year for three years to be ...

Promisingly, EpiTACs can also degrade G protein-coupled receptors ... about everything from the presence of aggregates to reaction kinetics, conformational changes, and the relative abundance ...

G protein-coupled receptors (GPCRs) are the largest and most diverse ... Then, with the help of multiplex chemical synthesis technology – basically, a series of chemical reactions for protein ...

Unfortunately, current pharmacological treatments for neuropathic pain lack clinical efficacy and often lead to harmful adverse reactions. As G protein-coupled receptors (GPCRs) are widely ...

Upon activation, MCs release a myriad of mediators responsible for creating a clinical picture of immediate reaction. Some of these mediators are preformed (histamine, proteases, heparin), whereas ...

CAR, chimeric antigen receptor; GPRC5D, G protein–coupled receptor, class C group 5 member D ... patients' peripheral blood was evaluated by quantitative polymerase chain reaction (Data Supplement).

Mast cell plays an important role in contact dermatitis and triggering pseudo-allergic reactions via MRGPRX2. Whether HQ induced skin irritant reaction through activating mast cells via MRGPRX2 ...

A reaction mixture (20 µL) of cDNA ... The lysate was centrifuged for 20 min, and the supernatant was collected as the total protein for immunoblotting. Subsequently, western blotting was performed ...

GPR31 (G-protein–coupled receptor 31)—a G-protein–coupled receptor ... Human Platelet RNA Extraction, cDNA Generation, and Quantitative Reverse Transcriptase Polymerase Chain Reaction (Real-Time ...