News

New cell signaling pathway found to shield blood vessels from hypertension damage
By creating artificial aging in mice, researchers at Lund University in Sweden have been able to track the formation of ...
Decades-old mystery solved: How Gram-negative bacteria keep their outer membrane intact
Researchers from the National University of Singapore (NUS) have solved a 60-year-old mystery in bacterial cell envelope ...
Breathing Problems: A Systemic Condition
All diseases exist on a continuum, and the damage often begins early—sometimes as soon as a child is weaned off breast milk ...
Protein split reveals dual roles in childhood ciliopathies and cell signaling
New research by Sumeda Nandadasa, Ph.D., reveals how a key protein associated with Meckel-Gruber syndrome, nephronophthisis, ...
The University of Alabama at Birmingham9d
In diseases due to exposure to toxic particles like gout, macrophages elicit separate pathways for inflammation and lysosomal function
In diseases due to exposure to toxic particles like gout, macrophages elicit separate pathways for inflammation and lysosomal ...
The EMBO Journal14d
Ageing, metabolism and the intestine - EMBO reports
The intestinal epithelium serves as a dynamic barrier to the environment and integrates a variety of signals, including those from metabolites, commensal microbiota, immune responses and stressors ...
gut.bmj19d
Bone marrow-mesenchymal stem cells are a major source of interleukin-7 and sustain colitis by forming the niche for colitogenic CD4 memory T cells - Gut
Objective Interleukin (IL)-7 is mainly produced in bone marrow (BM) that forms the niche for B cells. We previously demonstrated that BM also retains pathogenic memory CD4 T cells in murine models of ...
bjo.bmj25d
In vivo confocal microscopy of conjunctival goblet cells in patients with Sjögren's syndrome dry eye - British Journal of Ophthalmology
Background To study the morphology and the density of conjunctival goblet cells (GC) in patients with Sjögren's syndrome dry eye with in vivo laser scanning confocal microscopy (LSCM), and to explore ...
C&EN27d
Cognate Nanovaccine Promotes Tertiary Lymphoid Structures Function and Strengthens Immune Cell Cross-Talk by Targeting Exhausted T Cells in Nonimmunogenic ... - ACS Publications
Tertiary lymphoid structures (TLSs) serve as hubs for immune cell activation and coordination to generate qualitative local immune responses within tumors. However, the effect of TLSs in pancreatic ...
gut.bmj29d
Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis - Gut
As generation of the enormously large MUC2 polymeric network is time consuming and difficult, a high demand and fast turnover, as in inflammation, are likely to generate mucus of poorer quality. 37 ...