The researchers show that ephrin-B2 regulates the proper spatial activation of VEGFR-2 endocytosis and signaling at the tip cell filopodia. In vitro, endothelial cells from Efnb2-knockout and ...

Filopodia are specialized structures that extend from the cell membrane to allow a cell to explore the environment around it. These thin protrusions are full of a protein called actin, which, in ...

Computer simulations of filopodia dynamics indicate that a rotating actin structure inside the tube results in friction between the membrane and the actin, leading to the spiral form that is observed.