The American doctor has revealed that enigmatic DNA circles are present in more than half of patients with highly aggressive ...

the extrachromosomal DNA (ecDNA) found in some cancer cells is not always split evenly. Lacking centromeres, these circular bits of DNA are often unevenly parceled to daughter cells. Some daughter ...

The researchers analyzed changes to gene expression in ecDNA formed by HPV and human DNA hybridization in oropharyngeal tumor ...

Extrachromosomal circular DNA (ecDNA) occurs frequently across many cancer types, and while they have been known about for decades, Boundless Bio claims it is the first company to bring a therapy ...

Small circles of extrachromosomal DNA appear to be widespread in mammals, and may be byproducts of small deletions in the nuclear DNA of somatic cells. A series of rodent experiments showed that even ...

“We see firsthand that even when two patients both have MYC on ecDNA, the structure of that circular DNA can ... that organoids bearing MYC on extrachromosomal DNA could shift their dependency ...