Digoxin causes a prompt and considerable water and salt diuresis in congestive heart failure. This may occur with little or no change in renal hemodynamics, but usually is associated with decreased ...

It was not until the large DIG study of 1997 (Digitalis Investigation Group (1) that it was determined that digitalis (digoxin) really did have a beneficial effect in connection with heart failure.

The molecular signature of pathological hypertrophy is fetal gene induction, including changes in gene expression of contractile proteins and calcium handling that interfere with contractile function.

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