Notch activity can counteract VEGF-C-dependent (lymph)angiogenesis in KSHV-infected lymphatic endothelial cells, further supporting the central role of Notch signaling in cell fate determination.

Axon guidance cues direct nerves in the heart during development, disease and regeneration. These cues determine cardiac innervation patterning by regulating the balance between chemo-attraction and ...

were grown in endothelial cell medium (ECM) (Science Cell, Cat# 1001, USA) mixed with 10% FBS (Science Cell), 1% ECGS (Science Cell), and 1% P/S (Science Cell). Cells were cultured in a humidified ...

Upon activation, RXFP1 influences signaling pathways such as phosphoinositide 3-kinase (PI3K)/Akt and extracellular signal-regulated kinases (ERK), which may be involved ... that B7-33 might reduce ...

28 29 Genetic profiles, protein expression status, and cellular signaling pathways involved ... Trametinib, by inhibiting the MAP/ERK pathway, can prevent the abnormal proliferation of endothelial ...

"An exciting finding was when we tried to treat the obese mice with colon inflammation by lowering their inflammation, it actually stopped the ERK pathway in the liver from activating," explains Imai.

Tumor cells in colorectal cancer exploit an important signaling pathway that normally controls embryo development.

Memorial Sloan Kettering Cancer Center investigators report that T cell interferon-γ (IFNγ) orchestrates a dendritic-cell–natural-killer-cell circuit that suppresses leptomeningeal metastases in mouse ...

Jerry Brown and a panel of experts in 2021 that the state spend $5 billion annually to address ... This act of virtue-signaling leaves less funding to harden transmission lines while increasing ...