This state is mediated by a receptor on endothelial cells called Tie2. Under normal conditions, ANGPT2 prompts Tie2 to produce an anti-inflammatory response. However, these conditions are reversed ...

Endothelial cell inflammation causes vasodilation through ... Inflammation and coagulation are closely linked in sepsis. Inflammatory mediators generate tissue factor expression and initiate ...

one that helps mitigate sepsis: promoting stability of the endothelial barrier by restoring the tight junctions between endothelial cells that ordinarily regulate molecule transport and leakage.

APC, via the protein C pathway, is a natural homeostatic regulator with multiple mechanisms of action, making it a unique modulator of vascular function at the endothelial cell and leukocyte ...

When the immune system does not function properly, individuals become more susceptible to infections caused by viruses, ...

Researchers from Radboud university medical center have demonstrated that an existing drug can revive immune cells that are not ... care unit (ICU) with sepsis. Twenty percent of global deaths ...