The intensity of staining for the endothelial-cell markers CD31 and CD34 in the biopsy specimens from the patients with meningococcal sepsis was generally equivalent to that observed in the ...

The scientists found that the antibody against β1-integrin bound to the vascular endothelium, improved the junctions between endothelial cells and decreased vascular leakage in sepsis.

To find out, the researchers created mice lacking STIM1 in endothelial cells, and in a series of experiments, compared these mice to normal mice exposed to the sepsis toxin. They found that ...

Endothelial progenitor cells derived from bone marrow are believed ... 23 from cardiovascular causes (4.5 percent); other causes included sepsis (9 patients), chronic renal insufficiency (3 ...

In summary, the study reveals how sepsis-induced lactate production activates endothelial cells and promotes ferroptosis through H3K14 lactylation, ultimately leading to vascular injury and lung ...

Source: APOL 1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis Immunity DOI: 10.1016/j immune.2021.10.004 ...

leading to a disordered coaggregation of histone and PTX3 and protecting human endothelial cells from damage. Further, mice treated with PTX3 recovered from sepsis, showing that treatment with ...

The reason for organ failure in sepsis patients is because the endothelial cells lining blood vessels become leaky, resulting in abnormal fluid shifts which ultimately shut down the blood supply.

The scientists found that the antibody against β1-integrin bound to the vascular endothelium, improved the junctions between endothelial cells and decreased vascular leakage in sepsis.