For over a decade, scientists have been growing organoids—small clusters of cells that mimic a particular organ—to serve as ...

Researchers have developed a vascularized organoid model of hormone secreting cells in the pancreas. The advance promises to improve diabetes research and cell-based therapies.

In typical ALI/ARDS, the inflammatory response is primarily localized to the lungs, while sepsis-induced ALI/ARDS elicits a robust systemic immune response due to infection, resulting in more severe ...

However, its role in endothelial permeability and sepsis remains unknown. The cecal ligation and puncture model was applied to WT (wild type) and BMX-KO (BMX global knockout) mice to induce sepsis.

In summary, the study reveals how sepsis-induced lactate production activates endothelial cells and promotes ferroptosis through H3K14 lactylation, ultimately leading to vascular injury and lung ...

The reason for organ failure in sepsis patients is because the endothelial cells lining blood vessels become leaky, resulting in abnormal fluid shifts which ultimately shut down the blood supply.

The general pathology involves increased permeability of the endothelial cells of the pulmonary capillary and of the epithelial cells of the alveoli. Sepsis induced ARDS is often caused by ...

For several decades, studies of septic shock were modeled by investigating responses to bacterial LPS. In this model, LPS activates certain immune cells that trigger the production of inflammatory ...

Source: APOL 1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis Immunity DOI: 10.1016/j immune.2021.10.004 ...

The pathophysiology of sepsis-AKI involves multiple cell types, including macrophages, vascular endothelial cells (ECs) and renal tubular epithelial cells (TECs), etc. More significantly, programmed ...

Sepsis is a potentially life-threatening condition ... “Heat shock protein 27 activity is linked to endothelial barrier recovery after proinflammatory GPCR-induced disruption.” ...