APC, via the protein C pathway, is a natural homeostatic regulator with multiple mechanisms of action, making it a unique modulator of vascular function at the endothelial cell and leukocyte ...

This state is mediated by a receptor on endothelial cells called Tie2. Under normal conditions, ANGPT2 prompts Tie2 to produce an anti-inflammatory response. However, these conditions are reversed ...

Endothelial cell inflammation causes vasodilation through ... Inflammation and coagulation are closely linked in sepsis. Inflammatory mediators generate tissue factor expression and initiate ...

When the immune system does not function properly, individuals become more susceptible to infections caused by viruses, ...

whereas tools for vascular stabilization and prevention of capillary leakage in sepsis are scarce (Nat Rev Drug Disc, 2017, review). Integrins couple endothelial cells to the underlying vascular ...