The researchers analyzed how a prototype anti-flu drug called L-742,001 plugs into the critical functional region of the endonuclease, called the active site, to block its function. Investigators ...

Figure 1: Hypothetical model of the cation-π sandwich of the eukaryotic tRNA-splicing endonuclease. Figure 3: Model of the archaeal and eukaryotic tRNA-splicing endonuclease. Yeast tRNA-splicing ...

If the active site of the endonuclease is blocked by an inhibitor the enzyme cannot bind its normal substrate, the host cell mRNA, and viral replication is prevented. The active site of the ...

If the active site of the endonuclease is blocked by an inhibitor the enzyme cannot bind its normal substrate, the host cell mRNA, and viral replication is prevented. The active site of the ...

Using X-ray crystallography, we show how these inhibitors coordinate the two-metal endonuclease active site and engage the active site residues. Two structures also reveal an induced-fit mode of ...

Water will be required for the hydrolytic reaction, and several clearly defined water molecules are localized at the active site, the most notable being the single water molecule hydrogen-bonded ...

The researchers analyzed how a prototype anti-flu drug called L-742,001 plugs into the critical functional region of the endonuclease, called the active site, to block its function. Investigators ...