Syntichaki et al. used C. elegans having different mutated aspartyl proteases, and treated them with calpain inhibitors. They observed that neuronal degeneration inflicted by various genetic lesions ...

“It deserves all of the honor, but of course it will not be able to share the monetary award.” Dr. Brenner, often thought of as the father of C. elegans research, is the closest thing there is ...

The calpains are a conserved family of cysteine proteinases that catalyse the controlled proteolysis of many specific substrates that are involved in proliferation, apoptosis and migration ...

Calpain is there, it's activated, it's involved in all of these things," Zadran said. If Zadran has indeed settled the 25-year debate over calpain's relevance, she has done it in the blink of an eye.

Caenorhabditis elegans is a species of soil-dwelling nematode (roundworm) used as a model organism in molecular genetics and developmental biology. It is predominantly hermaphroditic (can self ...

21 Nov 2008 In this week’s issue of Nature, two groups report the crystal structure of the calcium-dependent protease calpain in complex with its endogenous inhibitor protein, calpastatin. Tudor ...

Non-canonical pattern recognition of a pathogen-derived metabolite by a nuclear hormone receptor identifies virulent bacteria in C. elegans. Immunity, 2023; DOI: 10.1016/j.immuni.2023.01.027 ...

Calpain 3 is suggested to be involved in maturation of contractile elements after muscle degeneration. The aim of this study was to investigate how mutations in the four functional domains of ...

AMX0114 is an investigational antisense oligonucleotide targeting calpain-2 (CAPN2), a calcium-activated protease believed to play a role in ALS disease progression.

Despite their prevalence, there are no antivirals on the market against enteroviruses, and vaccines have been developed only against couple of serotypes. The production of vaccines against all ...

Jing Huang, Neil E. Forsberg, Role of Calpain in Skeletal-Muscle Protein Degradation, Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, No. 21 (Oct. 13, 1998), ...

Calpain 3 was analyzed by western blot (Figure 2) using mouse anti-human calpain 3, clone 12A2 (Novocastra) recognizing the full size and 60 kDa bands and clone 2C4 recognizing full size and 30 ...