elegans has shown that nematode and mammalian models of channel-mediated toxicity share a common mechanism that involves a rise in intracellular Ca 2+ and the activation of calpain and cathepsin ...

Recent studies reestablish the importance to memory processes of calpain, a protease first hypothesized to play a crucial role in memory 25 years ago. A second high-profile paper in as many months ...

A staple in laboratories worldwide, C. elegans is “an experimental dream,” said one scientist. A staple in laboratories worldwide, C. elegans is “an experimental dream,” said one scientist.

[26–28] They found calpain 3 was not detected by western blotting, which is probably due to its degradation by nonsense-mediated mRNA decay. Three patients harbored two null alleles, and were ...

In a recent study published in Nature Communications, researchers identify an endogenous insulin antagonist that modulates fat loss in the roundworm Caenorhabditis elegans. How is information ...