These actions are induced by hormone binding extracellularly to the ANP receptor 1, thereby activating its intracellular guanylyl cyclase domain for the production of cyclic GMP 2. Here we present ...

A research team has identified a molecular mechanism that coordinates the operation of the N-methyl-D-aspartate (NMDA) ...

Researchers have revealed the mechanism underlying GPCR function using a GPS nuclear magnetic resonance (NMR) technique.

79 progress with new corticosteroid receptor-binding drugs Several compounds have been reported as a result of drug-discovery activities by both biotechnology companies and large pharmaceutical ...

Talin is a protein that plays an important role in the immune system by activating integrins, receptors that help cells ...

Novo Nordisk's GLP-1 receptor agonist semaglutide has been shown ... pointing to yet another potential use for the versatile drug class. The small, 48-subject study – published in the journal ...

Data Synthesis: Pharmacodynamic characteristics (glucocorticoid receptor binding) and lung delivery determine the relative clinical efficacy and pharmacokinetic properties (oral bioavailability ...

In this study, we developed a 3-D patient-specific model of abdominal aortic aneurysm (AAA) to evaluate the effect of US waves in enhancing the drug-containing microbubbles (MBs) adhered on the AAA ...

Consequently, combination therapy currently involves the administration of one cholinergic drug (donepezil, galantamine or rivastigmine) and one glutamatergic drug (memantine). There have been no ...

Traditionally, selectivity of oral or intravenous drugs relied on preferential drug-receptor binding. A novel approach exploiting image-guided techniques to impart spatial selectivity opens up a wide ...