Whereas the postsynaptic antagonist actions of OPC-4392 are ... conducted at each of the known molecular isoforms of the dopamine receptors in several transfection systems, as well as at novel ...

Among these, for example, the phenothiozines (which are antipsychotic dopamine receptor antagonists) showed clear connectivity and structure-function relationships despite the fact that none of ...

All patients had been exposed to a dopamine antagonist for at least 3 months prior to the onset of symptoms. Metoclopramide was second to only haloperidol in inducing TD and was responsible for 39 ...

It also develops AXS-05 (dextromethorphan-bupropion), an investigational N-methyl-D-aspartate receptor antagonist ... reuptake inhibitor and cortical dopamine modulator, which has completed ...