The mammalian liver has an extraordinary regenerative capacity, capable of fully restoring its mass and function after injury ...

As a postdoc, Komor found a way to achieve gene-editing with higher efficiencies and a lower incidence of indels by avoiding ...

Our evolutionary advantage over our primate relatives may come down to accelerated genetic expression in just six types of brain cells.

DNA's double helix has long stood as the symbol of life’s code. But buried within the genome lies a deeper level of complexity. One of the more intriguing discoveries in recent years is the i-motif—a ...

Harvard University researchers at the Broad Institute report that expansion in situ genome sequencing (ExIGS) linked nuclear ...

Endogenous intracellular allosteric modulators of GPCRs remain largely unexplored, with limited binding and phenotype data available. This gap arises from the lack of robust computational methods for ...

Mapping a human cell gives researchers a view of subcellular architecture and sheds light on how cancer develops.

BACKGROUND: Dilated cardiomyopathy (DCM) is substantially influenced by genetic factors. Sarcomere function is intricately associated with other organelles, particularly the reciprocal regulation ...

Genetic medicine reaches a major milestone with a system capable of inserting entire genes into human DNA. This breakthrough ...

Somatic hypermutation (SHM) of immunoglobulin variable (V) regions modulates antibody-antigen affinity is initiated by activation-induced cytidine deaminase (AID) on single-stranded DNA (ssDNA).

Ingrida Domarkienė, a geneticist at Vilnius University in Lithuania, discusses the exciting developments made possible by studying ancient and modern DNA.

The Human Genome Project has led to profound advances ... “If you have a broken radio and you have the circuit diagram, you’ll be in a better position to fix it,” he said in a statement.