The results show that Foxn1 not only plays a crucial role in development of the thymus in the embryo, but it also regulates vital functions in the developed, postnatal organ. Researchers at the ...

Researchers discover microbes regulate the development of specialized immune cells in the thymus that play a critical role in mucosal tolerance. Newborns face unique immunological challenges ...

Figure 1: A model of the early stages of T-cell development in the thymus. Figure 2: A model of the transitional stages that are associated with β-selection.

Despite its importance, little is known about the early development of the thymus, as it uniquely functions primarily during infancy and then gradually degenerates over the lifespan. Studying its ...

Thymic organogenesis is governed by the highly potent Tecs produced during early fetal development. The thymus is a critical organ of the immune system and helps the body fight against several ...

1 However, in that same year, Jacques Miller discovered that the thymus “regulates lymphocyte production” and thus plays a “very important part in the development of immunological response.” ...

The development of a transplantable and scalable artificial thymus organoid could position FibroBiologics as a leader in immunotherapy and chronic disease treatment, showcasing the company's ...

The thymus is one of the most important organs ... and function is necessary and could serve to further the development of cell-based therapies for thymic defects,” senior author Holger Russ ...

When the thymus doesn’t function properly, or if the organ does not form during fetal development, the result may include severe immunodeficiency, when the body cannot fight infectious diseases ...

On June 25, 2024, FibroBiologics, Inc. (NASDAQ:FBLG) announced positive proof-of-concept data regarding the development of a novel fibroblast-based artificial thymus organoid that can restore ...

HOUSTON, April 29, 2025 (GLOBE NEWSWIRE) -- FibroBiologics, Inc. (Nasdaq: FBLG) (“FibroBiologics”), a clinical-stage biotechnology company with 240+ patents issued and pending with a focus on ...