The results show that Foxn1 not only plays a crucial role in development of the thymus in the embryo, but it also regulates vital functions in the developed, postnatal organ. Researchers at the ...

Despite its importance, little is known about the early development of the thymus, as it uniquely functions primarily during infancy and then gradually degenerates over the lifespan. Studying its ...

Since the thymus is so important for immune system development during childhood, a thymectomy during childhood (before puberty) can also lead to issues. When this happens, people may have lower T ...

During their development, the immune cells migrate into and out of the thymus more than once. The zebrafish is thus an ideal animal model for studying the dynamic processes of immune cell development.

Figure 1: A model of the early stages of T-cell development in the thymus. Figure 2: A model of the transitional stages that are associated with β-selection.

Thymic organogenesis is governed by the highly potent Tecs produced during early fetal development. The thymus is a critical organ of the immune system and helps the body fight against several ...

The development of a transplantable and scalable artificial thymus organoid could position FibroBiologics as a leader in immunotherapy and chronic disease treatment, showcasing the company's ...

The thymus is one of the most important organs ... and function is necessary and could serve to further the development of cell-based therapies for thymic defects,” senior author Holger Russ ...

1 However, in that same year, Jacques Miller discovered that the thymus “regulates lymphocyte production” and thus plays a “very important part in the development of immunological response.” ...

On June 25, 2024, FibroBiologics, Inc. (NASDAQ:FBLG) announced positive proof-of-concept data regarding the development of a novel fibroblast-based artificial thymus organoid that can restore ...