Talchai and colleagues then described evidence of beta-cell dedifferentiation and loss of Foxo1 activity in two other mouse models of type 2 diabetes (leptin-receptor–deficient db/db mice and ...

[39] We have verified all of these endothelial cell culture experiments in transgenic mice that overexpress MnSOD (M.B., unpublished observations). When wild-type animals are made diabetic ...

In the experimental diabetic model, db/db male mice and non-diabetic control male mice (db/+) were subjected to caffeine or vehicle eye drops. Caffeine or vehicle eye drops were administered to ...

Strikingly, addition of SRI-37330 to the drinking water of obese diabetic db/db mice, a model of severe Type 2 diabetes, led within days to normalization of their blood glucose. Similarly, SRI-37330 ...

The untreated diabetic mice excreted nearly 10 times more albumin than the db/m mice, which was to be expected. However, the treated diabetic mice, who were fed the diet with chromium picolinate ...

The scientific team also demonstrated the therapeutic effects by experimenting on diabetic (db/db) mice. Treatment began by applying the device near the abdomen of the db mouse. Microneedles ...