Stanford scientists used machine learning to design improved zinc fingers that target disease genes while minimizing immunogenicity risk.

Designed DNA sequence–binding TALE domains can be used to construct either orthogonal transcriptional activators or repressors depending on the effector domain fused to the DNA-binding domain ...

Many different proteins can bind DNA, and they perform a variety of critical functions in cells. DNA-binding proteins often attach to specific places in the genome, and they may help respond to stress ...

Engineered nucleases, enzymes containing a nucleotide-specific DNA-binding domain fused to a non-specific DNA cleavage domain, are an essential component of genome editing. The product of nuclease ...

The central dogma of molecular biology dictates that information flows from DNA into RNA into protein in living cells. Transcription, a major tenet of this dogma, is the process by which information ...

Distinct structural bases for sequence-specific DNA binding by mammalian BEN domain proteins.Genes & Development 36, 225-240. Yu Y, Andreu-Agullo C, Liu BF, Barboza L, Toth M, Lai EC (2020).

If DNA bridges remain between chromosomes after cell division, chromosomes become improperly segregated, resulting in genetic instability and cancer.

Development of a methylation-based, tissue-free test for the detection of molecular residual disease by circulating tumor DNA.