News

Need a new 3D material? Build it with DNA
When the Empire State Building was constructed, its 102 stories rose above midtown one piece at a time, with each individual ...
Study uncovers how harmful RNA clumps form—and a way to dissolve them
Look inside a brain cell with Huntington's disease or ALS and you are likely to find RNA clumped together. These solid-like clusters, thought to be irreversible, can act as sponges that soak up ...
eLife12d
Erythrocytosis-inducing PHD2 mutations implicate biological role for N-terminal prolyl-hydroxylation in HIF1α oxygen-dependent degradation domain
Mutations in EGLN1, the gene encoding for hypoxia-inducible factor (HIF) prolyl-4-hydroxylase 2 (PHD2), cause erythrocytosis and in rare cases the development of neuroendocrine tumors. In the presence ...
eLife13d
p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration
The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...
Gene therapy may be key to permanently putting HIV into dormant state
In a study of human immune cells infected with HIV, the virus that causes AIDS, scientists at Johns Hopkins Medicine say a ...
C&EN20d
Sequence Requirements of the ATP-Binding Site within the C-Terminal Nucleotide-Binding Domain of Mouse P-Glycoprotein: Structure−Activity Relationships for Flavonoid Binding ...
Sequence requirements of the ATP-binding site within the C-terminal nucleotide-binding domain (NBD2) of mouse P-glycoprotein were investigated by using two recombinantly expressed soluble proteins of ...
RNA has newly identified role: Repairing serious DNA damage to maintain the genome
Your DNA is continually damaged by sources both inside and outside your body. One especially severe form of damage called a ...
C&EN24d
Solution Structure and DNA Binding Property of the Fifth HMG Box Domain in Comparison with the First HMG Box Domain in Human Upstream Binding Factor†, - ACS Publications
Human upstream binding factor (hUBF) is a nucleolar transcription factor involved in transcription by RNA polymerase I. It contains six HMG box domains. The contribution of each HMG box motif to its ...