When the Empire State Building was constructed, its 102 stories rose above midtown one piece at a time, with each individual ...

Look inside a brain cell with Huntington's disease or ALS and you are likely to find RNA clumped together. These solid-like clusters, thought to be irreversible, can act as sponges that soak up ...

In a study of human immune cells infected with HIV, the virus that causes AIDS, scientists at Johns Hopkins Medicine say a ...

FANCM employs a sophisticated dual recognition mechanism in genome maintenance, using distinct DNA-binding domains to identify and move around on branched DNA structures. This study reveals how FANCM ...

Functional dissection of the conserved C. elegans LEM-3/ANKLE1 nuclease reveals a crucial requirement for the LEM-like and GIY-YIG domains for DNA bridge processing.

The recombination between parental chromosomes, a characteristic of sexual reproduction, plays a crucial role in evolution. In mammals, a protein called PRDM9 is essential for this process. In ...

Epigenetics involves a series of biological processes that regulate chromatin-mediated DNA templates. 2 Cancer is a ...

The lysine/glutamic acid/arginine region in chromatin assembly factor (CAF-1) forms a long single alpha-helix DNA-binding domain, facilitating the recognition of tetrasome-length DNA and linking ...

The binding properties of biomolecules, which govern biological phenomena, are relevant for evaluating therapeutics, the team explained, but new experimental tools are needed to characterize, in a ...

The RGG domain is conserved in several G4 binding proteins, such as TLS/FUS, Ewing’s sarcoma protein (EWS), heterogeneous ribonucleoprotein A1, nucleolin, cold-inducible RNA-binding protein, Dbp2, ...