Designed DNA sequence–binding TALE domains can be used to construct either orthogonal transcriptional activators or repressors depending on the effector domain fused to the DNA-binding domain ...

The methyl-CpG-binding domain (MBD) proteins 'read' and interpret the methylation moieties on DNA, and thus are critical mediators of many epigenetic processes. Currently, the MBD family comprises ...

If DNA bridges persist between chromosomes during cell division, chromosomes are abnormally segregated, leading to genetic ...

The central dogma of molecular biology dictates that information flows from DNA into RNA into protein in living cells. Transcription, a major tenet of this dogma, is the process by which information ...

Many different proteins can bind DNA, and they perform a variety of critical functions in cells. DNA-binding proteins often attach to specific places in the genome, and they may help respond to stress ...

Engineered nucleases, enzymes containing a nucleotide-specific DNA-binding domain fused to a non-specific DNA cleavage domain, are an essential component of genome editing. The product of nuclease ...

PAX3 is a transcription factor (proteins involved in converting DNA into RNA) that drives melanoma progression by promoting cell growth, migration and survival, while inhibiting cellular terminal ...

Development of a methylation-based, tissue-free test for the detection of molecular residual disease by circulating tumor DNA.

PAX3 is a transcription factor (proteins involved in converting DNA into RNA) that drives melanoma progression by promoting cell growth, migration and survival, while inhibiting cellular terminal ...

New research has revealed that red blood cells function as critical immune sensors by binding cell-free DNA, called nucleic acid, present in the body's circulation during sepsis and COVID-19 ...

As more ORF1p molecules build up, they eventually envelop the LINE-1 RNA, which makes more binding sites available for the entire cluster to attach to DNA. "Our study provides crucial insight into ...

New research has revealed that red blood cells function as critical immune sensors by binding cell-free DNA, called nucleic acid, present in the body's circulation during sepsis and COVID-19 ...