We often take facts we learn — like the fact that transcription factors bind to DNA — for granted. Or maybe not. See how researchers used DNA footprinting and gel shift assays to prove this idea.

Sequence motifs are short, recurring patterns in DNA that are presumed to have ... and gel-shift or reporter construct assays, whereas binding affinities to artificial sequences were explored ...

To do so, they planned to stabilize proteins at their chromatin binding locations and use nucleic ... Following reversal of the crosslinks, they analyzed the DNA fragments using a dot blot ...

Scientists have identified promising drug candidates that bind irreversibly with a notoriously “undruggable” cancer protein ...