The bacteria that cause tuberculosis (TB) may have an "on-off switch" that lets them pause and restart growth, according to a ...

More information: Sophie L Williams et al, Replication‐induced DNA secondary structures drive fork uncoupling and breakage, The EMBO Journal (2023). DOI: 10.15252/embj.2023114334 ...

To fully understand how genome integrity is maintained, David Cortez, Ph.D., and colleagues have generated a "catalog" of the proteins present at sites of DNA duplication (replication forks ...

Furthermore, they also successfully improved the DNA to evolve to a DNA with a 10-fold increase in replication efficiency by continuing this DNA replication cycle for about 60 days. By adding the ...

Failures in DNA replication can lead to cancer, birth defects or other harm Video shows single pieces of double-helix DNA being copied Single-molecule view gives new insights into this process ...

The findings visualize for the first time a molecular complex -- called CTF18-RFC in humans and Ctf18-RFC in yeast -- that loads a 'clamp' onto DNA to keep parts of the replication machinery from ...

Knowledge of the structure of DNA enabled ... of 1 mM about 10 6 times per second). The rapid rates of molecular movement were thought initially to allow a process like DNA replication to occur ...

DNA must be replicated many times to give rise to the 4 × 10 13. DNA replication errors also accumulate in stem cells of adult organisms and are associated with ageing 2. Furthermore, although ...

The bacteria that cause tuberculosis (TB) may have an “on-off switch” that lets them pause and restart growth, according to a ...