Somatic hypermutation (SHM) of immunoglobulin variable (V) regions modulates antibody-antigen affinity is initiated by activation-induced cytidine deaminase (AID) on single-stranded DNA (ssDNA).

Figure 1: Mechanism of nucleotide excision repair and base excision repair. The protein factors that are required for TCR and general genome repair (GGR) of DNA damage fall into two broad groups.

In Biology 101, we learn that RNA is a single, ribbon-like strand of base pairs that is copied from our DNA and then read ...

Their model, called Difface, applies single DNA nucleotide differences to 3D facial point clouds, or sets of data points that represent the exterior surface of a face. When tested on a Han Chinese ...

Here we report the structure of an engineered replication terminator protein (RTP) of Bacillus subtilis in complex with a 21 base pair DNA by X-ray crystallography at 2.5 Å resolution.

Article continues after sponsor message On the cultural front, April 25, 1953, is notable for the publication of the discovery of the DNA double helix structure by James Watson and Francis Crick.

Key Laboratory of Soybean Molecular Design Breeding, National Key Laboratory of Black Soils Conservation and Utilization, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, ...