A recent study marks the first reported instance of generative AI designing synthetic molecules that can successfully control gene expression in healthy mammalian cells. As a proof-of-concept, the ...

This useful study employs AlphaFold2 to predict interactions among 20 nuage proteins, identifying five novel interaction candidates, three of which are validated experimentally through ...

revealed how a DNA-binding protein called RdfS forms helical structures or twisting forms that control the process of DNA transfer between agricultural bacteria. "DNA is literally cut out of one ...

The Center for Clinical Molecular Medical Detection, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P. R. China The Biobank Center, The First Affiliated Hospital of ...

When DNA is damaged, internal signals activate within the cell to pinpoint the damage and recruit specialized proteins—DNA repair "machines"—to fix the break. This repair process must be ...

The compound also enhanced the performance of the full mitochondrial replisome, including TWINKLE helicase and mitochondrial single-stranded DNA-binding protein (mtSSB). TWINKLE is a mitochondrial ...

The specific lipid composition of cell membrane microenvironments plays a critical role in regulating a range of cellular processes such as integral and peripheral membrane protein function ... device ...

Proteins change their conformations as part of their biological functions, for example, when binding another molecule (ligand). Two pathways are conceivable: Either the ligand binds preferentially to ...

This review highlights the critical role of misfolded protein species in ALS pathogenesis, particularly focusing on Cu/Zn superoxide dismutase (SOD1) and TAR DNA-binding protein 43 (TDP-43), and ...

This study aims to demonstrate the pivotal role of TraN key residues in sequence-specific DNA binding ... column pre-equilibrated with complex binding buffer using an ÄKTA pure 25-L chromatography ...