Historically, small molecule drugs have been precisely designed down to the atomic scale. Considering their relatively large complex structures, nanomedicines have lagged behind. Researchers argue ...

Historically, the vast majority of pharmaceutical drugs have been meticulously designed down to the atomic level. The ...

RNA-based technologies are a powerful molecular biology toolbox, empowering scientists to decipher the complexities of living ...

The RNA cloud formed around genes regulates their readout into RNA. Triplexes help define where in the genome a cloud forms. Proteins and other fl ...

SNAs are a globular form of DNA that can easily enter cells and bind to targets. More effective than linear DNA of the same sequence, SNAs have demonstrated significant potential in gene regulation, ...

Among the major classes of RNAs in the cell, tRNAs remain the most difficult to characterize via deep sequencing approaches, as tRNA structure and nucleotide modifications can each interfere with cDNA ...

A scientific revolution is underway as researchers push to bring atomic-level precision, once reserved for small molecule ...

Alkanediols such as 1,6-hexanediol disrupt many phase-separated condensates in cellula and in vitro, but how molecular interactions are perturbed by these compounds remains unclear. This study uses ...

Certain DNA sequences can form structures other than the canonical double helix. These alternative DNA conformations—referred ...

Ingrida Domarkienė, a geneticist at Vilnius University in Lithuania, discusses the exciting developments made possible by ...

An international research team has provided a detailed insight into how the spatial organization of genetic material is established in the cell nucleus of early embryos within the first hours after ...