Here, we show that the bulk of IFNγ-induced ADP-ribosylation depends on PARP14 catalytic activity and that PARP14 protein levels are regulated by the PARP9/DTX3L complex in concert with PARP14 itself.

Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilization, and human cancer cell survival in early hypoxia.

RAD51AP1 and RAD54L Can Underpin Two Distinct RAD51-Dependent Routes of DNA Damage Repair via Homologous Recombination ...

Add a description, image, and links to the jogopong-dm1a topic page so that developers can more easily learn about it ...

Efficacy of cytotoxic T lymphocyte (CTL)-based immunotherapy is still unsatisfactory against solid tumors, which are frequently characterized by condensed extracellular matrix. Here, using a unique 3D ...

Cavin3 associates with BRCA1 upon disassembly of caveolae in response to mechanical and non-mechanical stressors to influence DNA repair and apoptosis.

This article presents the various tools available to explore and understand the Tubulin Code via the function and dynamics of microtubules.

Sirtuins (SIRTs) are NAD-dependent deacylases, known to be involved in a variety of pathophysiological processes and thus remain promising therapeutic targets for further validation. Previously, we ...

Aneuploidy can cause chromosome mis-segregation and specific cellular phenotypes driven by expression of genes on the extra chromosome.

HP has introduced a new thin and light laptop with an 11.6 inch display and a low power AMD Neo processor. The HP Pavilion DM1a launches in Japan today, although the laptop is likely to carry a ...