This overabundance of cytokines can lead to inflammation ... Discovery that describes their initial findings. The proteins are similar in structure, and act in a similar way, to other proteins ...

This burst of immune overreaction, also called a cytokine storm, damages the lungs and can be fatal. A team of MIT researchers has developed specialized proteins, similar in structure to ...

The class II cytokine family consists of small α-helical signaling proteins including the interleukin ... by using information contained within the structure of those molecules.

Figure 1: The structure and function of SOCS proteins ... inflammation-associated tumorigenesis. The use of SOCS proteins to suppress cytokine signalling could be a useful therapy for the ...

They have obtained the first structure of p38α being activated by another regulatory protein kinase – MKK6 – opening up new directions to develop drugs to stop cytokine storms. The final ...

Published in the journal Science, the structure reveals the mechanism by which this protein, Janus kinase (JAK), transmits signals sent by immune cell growth factors called cytokines.

For example, structure-modified superkines with increased ... chimeric antibody-cytokine fusion proteins or infusion of anti-cytokines in association with cytokines are being investigated to ...

BRCA DNA-repair proteins interact ... By probing the detailed structure of the complex, the team found that SHMT2 also induces immune cells to send out cytokines through its interaction with ...

The major cell types and cytokine ... is a fusion protein made up of two recombinant p75 soluble TNF receptors fused with the Fc portion of human IgG1. The dimeric structure of etanercept makes ...