During early drug development and preclinical development, researchers use in vitro cultured lymphocytes to induce cytokine ...

Cytokine traps block cytokine action in vivo We first evaluated the in vivo activity of the human IL-1 trap by testing its ability to block the biological actions of human IL-1β administered SC ...

Inherited variation in genes encoding cytokines and cytokine receptors and their respective JAKs and STATs are associated with a significantly increased risk of immune-mediated disease.

Cytokine actions may be autocrine meaning the cytokine acts on the same cell that secretes it. If the cytokine acts on cells nearby other than the one that secreted it, the action is termed paracrine.

Hundreds of cytokines are released when the immune system goes into action. They drive and suppress one another in complex feedback loops.

Rheumatoid arthritis is a common chronic inflammatory and destructive arthropathy that cannot be cured and that has substantial personal, social, and economic costs. The long-term prognosis is poor ...

Cytokine release syndrome is an immune system response that can occur due to immunotherapy or infection. It happens when an immune system communication protein called cytokine is overproduced.

Cytokine release syndrome (CRS) occurs due to high levels of inflammation in the body. Find out about the symptoms of CRS and how it links to COVID-19 here.

It is possible that metabolic stressors increase cytokine action or reduce cytokine antagonist activity and increase free radical production.

In the quest to design vaccines that better help the body's immune system fight disease, scientists are always looking for more tools for their arsenal.

Furthermore, cytokines can exhibit synergistic effects, where one cytokine enhances the activity of another, or antagonistic effects, where one cytokine inhibits the action of another. This complex ...