Cytokine traps block cytokine action in vivo. We first evaluated the in vivo activity of the human IL-1 trap by testing its ability to block the biological actions of human IL-1β administered SC ...

During early drug development and preclinical development, researchers use in vitro cultured lymphocytes to induce cytokine ...

Cytokine actions may be autocrine meaning the cytokine acts on the same cell that secretes it. If the cytokine acts on cells nearby other than the one that secreted it, the action is termed paracrine.

Agents that block the action of specific cytokines have changed the lives of many patients with rheumatoid arthritis and other autoimmune disorders. But frequent self-injections or injections by a ...

This action elicits a further increase in neuronal APP expression and induces the expression of interleukin-23 and interleukin-12, two other proinflammatory cytokines that share a common subunit p40.

Inflammatory stimuli -- cytokines or activation of inflammatory signaling pathways -- had been thought to help drive the development of obesity and type 2 diabetes.

This receptor, which receives signals from the cytokine interleukin 1, ... The problem is that the body becomes resistant to cytokine signaling, rather than cytokine action being the problem." ...

Hundreds of cytokines are released when the immune system goes into action. They drive and suppress one another in complex feedback loops. “You take this thing like spaghetti that is connected ...

These chemicals, called cytokines, drive the inflammation in the brain, attracting more immune cells, ... "The study demonstrates a new mechanism of action for INF-β therapies," says Dr. Rostami.

Cytokine release syndrome is an immune system response that can occur due to immunotherapy or infection. It happens when an immune system communication protein called cytokine is overproduced.

Expert Rev Endocrinol Metab. 2008;3(2):147-159. Inflammatory or immunological factors appear to be implicated in insulin resistance and decreased β-cell function. [37] Compared with nondiabetic ...

Cytokine release syndrome (CRS) occurs due to high levels of inflammation in the body. Find out about the symptoms of CRS and how it links to COVID-19 here.