Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Genome-wide association studies (GWASs) have ...
CRISPR technology has radically transformed genetic research, and at the forefront of this transformation is CRISPR screening. This method empowers scientists to systematically explore gene functions, ...
Additionally, we used CRISPRa to overexpress insect developmental genes which, which results in complete lethality. We first did this as a proof of concept in flies, and we showed that this works in ...
It makes CRISPR/Cas9 a convenient tool for genetic knockout. First generation CRISPRa systems consist of two components: dCas9 fused with transactivator and sgRNA (Figure 1B). Whereas the design of ...
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