IRBM is a contract research organization (CRO) focused on early-stage drug discovery. With a track record of delivering ...

Full details of the work are published in a new Cell Stem Cell paper titled, “Self-organization of embryonic stem cells into reproducible pre-gastrulation embryo models via CRISPRa programming.” ...

Reference: Lodewijk GA, Kozuki S, Han CJ, et al. Self-organization of mouse embryonic stem cells into reproducible pre-gastrulation embryo models via CRISPRa programming. Cell Stem Cell. 2025. doi: 10 ...

New gene transcriptional regulation tools are under development, including CRISPR interference (CRISPRi), and CRISPR activation (CRISPRa), as well as novel Base Editor (BE), Prime Editor (PE ...

Reference: “Self-organization of mouse embryonic stem cells into reproducible pre-gastrulation embryo models via CRISPRa programming” by Gerrald A. Lodewijk, Sayaka Kozuki, Clara J. Han, Benjamin R.