Figure 1: Phylogenetic tree of class II cytokines and receptors. Figure 2: Three-dimensional structure of monomeric and dimeric class II cytokines. Figure 3: Schematic representation of the ...

2). In contrast, the amount of IL-28 and ... COS-7 cells were transfected with class II cytokine receptor cDNAs as pools of all possible heterodimeric receptor pairs (IFNAR1, IFNAR2, IFN-γR1 ...

The excessive cytokine production leads to hyperinflammation and multiorgan failure. Regulatory cell types, decoy receptors for proinflammatory ... types 1, 2, 9, and 17 helper T (Th1, Th2 ...

Initial recognition of antigens is mediated by specific receptors ... from producing cytokines, as well as inhibiting their expression of major histocompatibility complex (MHC) class II molecules ...

“EQ101 is a first-in-class, tri-specific cytokine inhibitor selectively targeting IL-2, IL-9 and IL-15 at the receptor level, that may afford significant advantages over other treatment ...

The Interleukin-1 Receptor-Like 2 (IL-1RL2) cytokine can promote inflammatory diseases and have a role in controlling infection. The receptor can recognize multiple agonists and has been ...

This approach provides multi-cytokine inhibition at the receptor level and ... a first-in-class, selective, tri-specific inhibitor of IL-2, IL-9 and IL-15, and EQ102, a first-in-class, selective ...

Cytokines are a class of small proteins ... directly to fight cancer cells, and (2) anticytokine therapy, where the antagonists of cytokines or cytokine receptors are controlled to curb the ...

2 Because erythropoietin, thrombopoietin, growth hormone, prolactin, and leptin use the same class of receptor, they can also be included in this family of cytokines. Other cytokines, such as ...

Cytokines are a key area of interest in cancer immunotherapy. Interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15, and IL-21 comprise a cytokine family based on a shared receptor component, the common ...

The proteins work by mimicking six different cytokine receptors, allowing them to bind to a wide range of cytokines, such as interferon, interleukin, and a class called chemokines.

Garcia’s lab has determined the 3D structures of many cytokine-receptor complexes, including interleukins 1, 2, 4, 6, 13, 17 and 23. “He takes it a step beyond that, modifying the cytokine to ...