Vepdegestrant, an investigational estrogen receptor (ER) degrader, known as a proteolysis-targeting chimera (PROTAC ), ...

Find more information on the Altmetric Attention Score and how the score is calculated. G protein-coupled receptors (GPCRs) transduce information encoded by external stimuli into an appropriate cell ...

Pharmaceutical Sciences Division, The University of Wisconsin-Madison, 777 Highland Ave., Madison, Wisconsin 53705, United States Wisconsin Center for NanoBioSystems, The University of ...

TWEAK (tumour necrosis factor (TNF)-like weak inducer of apoptosis) is a member of the TNF superfamily of structurally related cytokines. It is present on the cell surface but a soluble form can ...

In this phase 2, randomized, placebo-controlled trial, participants with narcolepsy type 1 received once- or twice-daily oveporexton (TAK-861), an oral orexin receptor 2–selective agonist ...

Participants (n = 58) were a median of 67 years of age (22-88), 72% had lymphoma, 28% had multiple myeloma, and they were a median of 2 years (1-4.7) post-CAR T-cell infusion. Most of the participants ...

Results from a phase 2 study of triplet blockade of the IL-27, PD-(L)1, and VEGF pathways with casdozokitug (casdozo, SRF388) in combination with atezolizumab (atezo) and bevacizumab (bev) in patients ...

Weak Hero Class 2 has taken raw intensity and compelling characters to the next level. Each confrontation between the characters has left the fans breathless, as Si-eun’s new school has also thrown ...

Researchers have discovered distinct roles for two dopamine receptors located on nerve cells within the portion of the brain that controls approach vs. avoidance behavior. Mount Sinai researchers ...