Abstract: We present optimisations applied to a bespoke bio-physical molecular dynamics simulation designed to investigate chromosome condensation. Our primary focus is on domain-specific algorithmic ...

In early mitosis, CR1 motifs in receptors Sgo1 and Lrs4 recruit condensin to pericentromeres and rDNA, to facilitate sister kinetochore biorientation and rDNA condensation, respectively. We ...

Their results provide a novel insight into mitotic chromosome condensation in living human cells. Their work is published in the journal Proceedings of the National Academy of Sciences on August ...

Their results provide a novel insight into mitotic chromosome condensation in living human cells. Their work is published in the journal Proceedings of the National Academy of Sciences (PNAS ...

In the chromosome condensation process, chromatin strands are compacted into short chromosomes. This process makes the chromosomes rigid to resist the pulling force from the spindle. While several ...

The identification of the principle of chromosome condensation in this work is the stepping stone to understanding chromatin dynamics during the course of the cell cycle," says Dr. Amanda Camara.

In a collaborative paper in PNAS, Yves Barral with Jorrit Enserink and the Chymkowitch group in Norway shows that the effects on transcription of chromosome condensation during mitosis, is not just a ...

During mitosis, chromosomes ensure that the genetic material is equally divided among the daughter cells. Interestingly, the dimensions and degree of DNA condensation in mitotic chromosomes vary from ...

Our chromosome two, for example, was fused from two separate ones, yet the tweak isn’t present in the gorilla, our close evolutionary cousin. The new study aimed to do one better than evolution: using ...

Therefore, the condensation of chromosomes is essential to accurately transmitting genetic information. A research team led by Professor Changyong Song and Dr. Daeho Sung, and Professor Jae-Hyung Jeon ...