Mapping a human cell gives researchers a view of subcellular architecture and sheds light on how cancer develops.

Somatic hypermutation (SHM) of immunoglobulin variable (V) regions modulates antibody-antigen affinity is initiated by activation-induced cytidine deaminase (AID) on single-stranded DNA (ssDNA).

Two views of an expanded skin cell nucleus from a person with progeria: On the left, antibody fluorescence imaging shows the ...

Northwestern Medicine scientists have uncovered new details about the genetic structure of ovarian cancer stem cells, according to a study published in Advanced Science. Inside cells, DNA mixes ...

Preliminary data from Parse’s chromatin assay showing clustering of mouse brain nuclei based on DNA accessibility profiles. (Graphic: Business Wire) SEATTLE, March 04, 2025--(BUSINESS WIRE ...

Immune cells in the blood may be intimately involved with Alzheimer’s pathogenesis in the brain. At least, according to their chromatin. A study published January 31 in Neuron reported that in people ...

Cell behavior is influenced by chromatin architecture—the 3D shape of chromosomes—and which genes are accessible to proteins that promote regulatory T cell development. Studies involving ...

Applying this pipeline to intravital imaging data allowed us to quantify chromatin compaction within individual nuclei, among a population of stem cells, and between distinct cell identities based on ...

Salk Institute researchers have developed a new genomic technology to simultaneously analyze the DNA, RNA and chromatin—a combination of DNA and protein—from a single cell. The method, which took five ...

One trans‐acting locus on Chr 12 primarily impacted chromatin accessibility in embryonic stem cells, while in epiblast‐like cells ... and RNA read depth from merged replicates. Locations of Chr 7 ...

In a study published in Cell Reports, they and their colleagues show that the chromatin environment on DNA—the combination of DNA and histone proteins—plays a key role enforcing cell fate ...