Chromatin state differences between cell types relate to cell-type-specific ... state (4 or 5), was within 125 kb of a TSS, excluding locations within 5 kb, and was associated with a gene ...

Both cell type and developmental stage can be deduced from measurements of chromatin accessibility in thousands of single cells, researchers at EMBL and the University of Washington show.

However, the structure of chromatin also appears to serve a second, possibly more important role, in that it gives eukaryotic cells the capability to exert complex levels of control over gene ...

Maintaining cells in the quiescent G 0 phase of the cell division cycle is achieved by suppressing the expression of genes required for cell-cycle progression. In the May 10 Science, Hidesato Ogawa ...

Harvard University researchers at the Broad Institute report that expansion in situ genome sequencing (ExIGS) linked nuclear ...

Open chromatin profiling key to identifying leukemia cells of origin Date: July 11, 2016 Source: Jackson Laboratory Summary: Researchers have found a precise and reliable way -- whole-genome ...

Northwestern Medicine scientists have uncovered new details about the genetic structure of ovarian cancer stem cells, according to a study published in Advanced Science. Inside cells, DNA mixes ...

Cell behavior is influenced by chromatin architecture—the 3D shape of chromosomes—and which genes are accessible to proteins that promote regulatory T cell development. Studies involving ...

Proteins interact with DNA to regulate many vital processes in cells. Nearly 40 years ago ... To do so, they planned to stabilize proteins at their chromatin binding locations and use nucleic acid ...

More specifically, they had a hunch that DNA packaging -- how the strands are wrapped, coiled, and condensed inside the nucleus of a cell -- could be cancer’s “Achilles heel.” "If you think of ...

Backman's solution alters chromatin's structure in a way that prevents cancer from evolving to withstand treatment, making the disease an easier target for existing drugs. If the cells cannot ...

Scientists at the Salk Institute say they have discovered that the Foxp3 protein is essential for creating the unique chromatin architecture of regulatory T cells and, in turn, promoting their ...