Hosted on MSN26d
Chromatin fiber's genomic 'memory' governs the building blocks of life, study reveals
The scientists observed that chromatin self-organizes into "packing domains"—distinct, compact regions of molecular structures that play a crucial role in regulating gene expression.
The EMBO Journal13d
Nanoscale analysis of human G1 and metaphase chromatin in situ
G1 nucleosomes are concentrated in globular chromatin domains, and metaphase nucleosomes are concentrated in the chromatids. Classification analysis reveals that canonical mononucleosomes, and in some ...
60 genes implicated in congenital heart disease, including some that also contribute to related disorders such as autism
Congenital heart disease (CHD) is one of the most common birth defects, but the full extent of its genetic underpinnings has ...
AZoLifeSciences on MSN6d
UV Light Reshapes 3D Genome Structure, Altering DNA Repair and Gene Activity
Research shows UV radiation modifies 3D genome structure, affecting DNA damage response and gene activity, offering insights ...
eLife17d
Genome organization by SATB1 binding to base-unpairing regions (BURs) provides a scaffold for SATB1-regulated gene expression
Remarkably, while they lose all previously mapped signals for SATB-1 in active chromatin, they now gain many binding events in silent regions of the genome, represented by lamin-associated domains ...
The Scientist18d
Pluripotency Superstar Oct4 Gets a Makeover
The second act of a popular reprogramming factor could maximize the potential of iPSCs in research and regenerative medicine.
Frontiers3d
Chromatin-associated cullin-RING E3 ubiquitin ligases: Keeping transcriptionally active NF-κB in check
This termination can be facilitated through the ubiquitination and subsequent proteasomal degradation of chromatin-bound RelA ... SOCS-box proteins with structurally similar WD40 repeat domains, ...